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Multimodal strategies for diagnosis, stratification, and therapeutic monitoring in ALS
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DOI：10.1016/j.neubiorev.2026.106727.png)
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Abstract
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• Genetic mutations, neuroinflammation and metabolic dysfunction converge as key ALS mechanisms • Multimodal biomarkers are transforming ALS diagnosis and patient stratification • Integrating biofluids, omics and imaging improves disease monitoring • Biomarker-driven approaches can enhance clinical trial design and outcomes • A unified framework is proposed for precision medicine in ALS
Keywords:
Amyotrophic lateral sclerosis
neurodegeneration
motor neuron
biomarkers
precision medicine
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