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Multiple mild heat-shocks decrease the Gompertz component of mortality in Caenorhabditis elegans
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DOI：10.1016/j.exger.2009.06.007.png)
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Abstract
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Exposure to mild heat-stress (heat-shock) can significantly increase the life expectancy of the nematode Caenorhabditis elegans. A single heat-shock early in life extends longevity by 20% or more and affects lifelong mortality by decreasing initial mortality only; the rate of increase in subsequent mortality (Gompertz component) is unchanged. Repeated mild heat-shocks throughout life have a larger effect on life span than does a single heat-shock early in life. Here, we ask how multiple heat-shocks affect the mortality trajectory in nematodes and find increases of life expectancy of close to 50% and of maximum longevity as well. We examined mortality using large numbers of animals and found that multiple heat-shocks not only decrease initial mortality, but also slow the Gompertz rate of increase in mortality. Thus, multiple heat-shocks have anti-aging hormetic effects and represent an effective approach for modulating aging. (C) 2009 Elsevier Inc. All rights reserved.
Keywords:
Heat-shock
Gompertz
Mortality
Caenorhabditis elegans
Hormesis
Caloric restriction
Stress
Stressors
Initial mortality
Demography
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