.png){kind=icon}
.png){kind=icon}
Return
Multiple sclerosis: doubling down on MHC
.png){kind=icon}
OA
AI
DOI：10.1016/j.tig.2021.04.012.png)
.png){kind=icon}
.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
Human leukocyte antigen (HLA)-encoded surface molecules present antigenic peptides to T lymphocytes and play a key role in adaptive immune responses. Besides their physiological role of defending the host against infectious pathogens, specific alleles serve as genetic risk factors for autoimmune diseases. For multiple sclerosis (MS), an autoimmune disease that affects the brain and spinal cord, an association with the HLA-DR15 haplotype was described in the early 1970s. This short opinion piece discusses the difficulties of disentangling the details of this association and recent observations about the functional involvement of not only one, but also the second gene of the HLA-DR15 haplotype. This information is not only important for understanding the pathomechanism of MS, but also for antigen-specific therapies.
Keywords:
MYELIN BASIC-PROTEIN
T-CELL RECOGNITION
STRUCTURAL BASIS
CLASS-I
HLA-DR
SEQUENCE-ANALYSIS
PEPTIDE
ANTIGEN
RESTRICTION
HLA-DR2
AI Summary
Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.
Journal
IF:
16.3
Papers:
3.4K
Citations:
1.5W
View more organizations