Multiplexed miRNA imaging using spherical nucleic acids and catalytic hairpin assembly for screening the differential immunotoxicity of deoxynivalenol and its acetylated derivatives in RAW264.7 cells

Tao Liu

doi:10.1016/j.bios.2026.118994

Multiplexed miRNA imaging using spherical nucleic acids and catalytic hairpin assembly for screening the differential immunotoxicity of deoxynivalenol and its acetylated derivatives in RAW264.7 cells

2026-07-04

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AI

T

Tao Liu

J

Jiadi Sun *

K

Kuan Chang

Y

Yongli Ye

C

Caihong Huang

X

Xiulan Sun *

DOI：10.1016/j.bios.2026.118994

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• Spherical nucleic acids (SNAs)-driven catalytic hairpin assembly (CHA) enables multiplexed imaging of miR-155 and miR-210 in living RAW264.7 cells. • Enzyme-free signal amplification based SNAs-CHA with LODs of 0.033 nmol/L (miR-155) and 0.026 nmol/L (miR-210) in vitro, respectively. • Low-dose exposure (0.05–2 μmol/L) to DON, 3-Ac-DON, and 15-Ac-DON induces time-dependent upregulation of miR-155 and miR-210 in vivo. • Dual-miRNA imaging provides a novel strategy for early screening of immunotoxicity induced by DON and its acetylated derivatives.

Multiplexed miRNA imaging using spherical nucleic acids and catalytic hairpin assembly for screening the differential immunotoxicity of deoxynivalenol and its acetylated derivatives in RAW264.7 cells

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