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Multispectral Molecular Chiral Barcoding
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DOI：10.1002/adma.202409565.png)
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Abstract
En 中文
More than half of pharmaceutical drugs in use are chiral, necessitating accurate techniques for their characterization. Enantiomers, molecules with mirrored symmetry, often exhibit similar physical traits but possess distinct chemical and biological implications. This study harnesses the strong light-matter interaction induced by superchiral light to perform Surface-Enhanced Infrared Absorption (SEIRA) induced vibrational circular dichroism measurements in the mid-infrared spectral region. Utilizing a nanopatterned pixelated array of achiral plasmonic nanostructures, the system allows unique identification of enantiomers and biomolecules. Tunability of plasmon resonance facilitates spectral variation of the optical chirality over a wide infrared range, enabling development of a unique chiral barcoding scheme to distinguish chiral molecules based on their infrared fingerprint. This simple, yet robust sensor presents a low-cost solution for chiral mapping of drugs and biomolecules. A unique chiral sensing platform is introduced that utilizes a pixelated array of achiral plasmonic nanostructures to perform Surface-Enhanced Infrared Absorption (SEIRA) and Vibrational Circular Dichroism (SEVCD) in the mid-infrared range. This method enables the unique identification of enantiomers and biomolecules through a chiral barcoding scheme, offering a robust, low-cost solution for drug and biomolecule detection. image
Keywords:
chirality
nanofabrication
plasmonics
SEVCD
Journal
IF:
26.8
Papers:
3.4W
Citations:
46.0W
