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Muscle Ultrasound Parameters and Cognitive Function in H‑type Hypertension: A Cross-Sectional Study
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DOI：10.2147/cia.s615425.png)
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Abstract
En 中文
Xiao-Fen Weng,1,* Song-Tao Li,2,* Yan Cui,1 Yun-Long Yang,1 Zheng Xie,1 Jing-Yi Hu,3 Shan-Wen Liu,4 Hua Hu,4 Yong-Hua Wu,1 Li-Ya Mo1 1Department of Geriatric Medicine, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, Jiangsu, People’s Republic of China; 2Department of General Practice, Pingjiang New Town Community Health Service Center, Suzhou, Jiangsu, People’s Republic of China; 3Ultrasound Center, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, Jiangsu, People’s Republic of China; 4Department of Neurology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People’s Republic of China *These authors contributed equally to this work Correspondence: Yong-Hua Wu; Li-Ya Mo, Department of Geriatric Medicine, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, Jiangsu, 215000, People’s Republic of China, Email wuyonghuageriatric@163.com; yaya.172@163.com Background: H-type hypertension is associated with an increased risk of cognitive impairment, but the relationship between muscle ultrasound parameters and cognitive function in this population remains unclear. This cross-sectional study investigated the association between muscle ultrasound parameters and cognitive function in patients with H-type hypertension and sought to identify ultrasound parameters associated with cognitive status. Methods: This cross-sectional study included 125 patients with H-type hypertension. Cognitive function was assessed using the Montreal Cognitive Assessment (MoCA). Participants were classified into non-cognitive impairment (n = 68) and cognitive impairment (n = 57) groups. Muscle thickness (MT), muscle cross-sectional area (MCSA), shear wave velocity (SWV), and pennation angle (PA) were measured at selected upper- and lower-limb muscles. Partial correlation analysis, multivariable linear regression, and binary logistic regression were performed to examine associations between ultrasound parameters and cognitive status. Results: Compared with the non-cognitive impairment group, the cognitive impairment group had significantly lower MT and MCSA at multiple sites, including the biceps brachii, brachioradialis, rectus femoris, and lateral gastrocnemius (all P < 0.05), whereas SWV and PA did not differ significantly. After adjustment, rectus femoris MT showed the strongest correlation with total MoCA score (r = 0.470, P < 0.001). Rectus femoris MT remained independently associated with total MoCA score (B = 0.509, 95% CI: 0.330– 0.688, P < 0.001) and cognitive impairment (OR = 0.811, 95% CI: 0.706– 0.933, P = 0.003). Conclusion: Reduced rectus femoris MT is independently associated with poorer cognitive function and the presence of cognitive impairment in patients with H-type hypertension. Rectus femoris MT may serve as a useful adjunctive ultrasound marker of concurrent cognitive status, but prospective studies are needed to determine its clinical utility. Keywords: H-type hypertension, cognitive function, muscle ultrasound, rectus femoris, MoCA
Keywords:
H-type hypertension
cognitive function
muscle ultrasound
rectus femoris
MoCA
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