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MuSK antibodies differently affect the MuSK signaling cascade depending on valency and epitope specificity

delete2026-07-02
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OA
AI
D
Dana L.E. Vergoossen
R
Robyn Verpalen
S
Stine Marie Jensen
S
Sandra Fonhof
Y
Yvonne E. Fillié‐Grijpma
C
Christoph Gstöttner
E
Elena Dominguez-Vega
S
Silvère M. van der Maarel
J
Jan J.G.M. Verschuuren
M
Maartje G. Huijbers *
DOI：10.1016/j.jaut.2026.103593delete
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Abstract

Abstract

En 中文
• Antibody valency and epitope affect MuSK activation and interaction with Dok7. • Antibody valency affects expression of NMJ-specific genes in a MuSK MG mouse model. • The unique composition of MuSK antibodies in patients influences the pathomechanism. • Understanding antibody traits related to MuSK function may aid therapy development.
Keywords:
Myasthenia gravis
IgG4
Autoimmune disease
Autoantibodies
MuSK
Neuromuscular junction

Journal

Journal of Autoimmunity cover
Journal of Autoimmunity
IF:
7
Papers:
3.1K
Citations:
1.0W

Organization

L
leiden university medical center
Scholars:
1.1K
Papers: 378
Citations: 0
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