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MuSK antibodies differently affect the MuSK signaling cascade depending on valency and epitope specificity
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DOI：10.1016/j.jaut.2026.103593.png)
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Abstract
En 中文
• Antibody valency and epitope affect MuSK activation and interaction with Dok7. • Antibody valency affects expression of NMJ-specific genes in a MuSK MG mouse model. • The unique composition of MuSK antibodies in patients influences the pathomechanism. • Understanding antibody traits related to MuSK function may aid therapy development.
Keywords:
Myasthenia gravis
IgG4
Autoimmune disease
Autoantibodies
MuSK
Neuromuscular junction
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