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Mutation specific impairment of fatty acid and pyruvate oxidation in hypertrophic cardiomyopathy mouse models
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DOI：10.1016/j.yjmcc.2026.06.005.png)
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Abstract
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• NMR-based triple tracer approach yields mutation specific differences in metabolic flux • MyHC-mutant hearts show reduced substrate use, PDH flux, and PCr/ATP ratios • MyHC related defects resemble those associated with overpressure-related HF • TnT-mutant hearts maintain normal substrate use, PDH flux, and PCr/ATP ratios • HCM related mutations can manifest as allele-specific metabolic phenotypes
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