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MYC: a complex problem
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DOI：10.1016/j.tcb.2022.07.006.png)
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Abstract
En 中文
The MYC protooncogene functions as a universal amplifier of transcription through interaction with numerous factors and complexes that regulate almost every cellular process. However, a comprehensive model that explains MYC's actions and the interplay governing the complicated dynamics of components of the transcription and replication machinery is still lacking. Here, we review the potency of MYC as an oncogenic driver and how it regulates the broad spec-trum of complexes (effectors and regulators). We propose a 'hand-over model' for differential partitioning and trafficking of unstructured MYC via a loose interaction network between various gene-regulatory complexes and factors. Additionally, the article discusses how unstructured-MYC energetically favors efficient modulation of the energy landscape of the transcription cycle.
Keywords:
RNA-POLYMERASE-II
C-MYC
N-MYC
EMBRYONIC LETHALITY
TRANSCRIPTIONAL ACTIVATION
HISTONE ACETYLTRANSFERASE
NUCLEOTIDE-SEQUENCES
PROTEIN STABILITY
DNA-REPLICATION
GENE-REGULATION
Journal
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18.1
Papers:
3.1K
Citations:
2.0W
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Cited Papers
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EMBO JOURNALOAAI
EMBO JOURNALIF8.3
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