Myocardial Native T1 Mapping in the German National Cohort (NAKO): Associations with Age, Sex, and Cardiometabolic Risk Factors

2026-07-23

Clemens Ammann

Jan Gröschel

Hadil Saad

Susanne Rospleszcz

Christopher Schuppert

Thomas Hadler

Richard Hickstein

Thoralf Niendorf

Janis M. Nolde

Matthias B. Schulze

Karin Halina Greiser

Hermann Brenner

Ute Mons

Josua A. Decker

Thomas Kröncke

Thomas Küstner

Konstantin Nikolaou

Stefan N. Willich

Thomas Keil

Marcus Dörr

DOI：10.1016/j.jocmr.2026.102781

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In cardiovascular magnetic resonance (CMR), myocardial native T1 mapping enables quantitative, non-invasive tissue characterization and is sensitive to subclinical changes in myocardial structure and composition. However, data on the association between cardiometabolic risk and myocardial alterations are still limited. We therefore investigated how age, sex, and cardiometabolic risk factors are associated with myocardial T1 as a potential imaging marker of myocardial target-organ involvement in a population-based analysis within the German National Cohort (NAKO).

Keywords:

AHA

American Heart Association

artificial intelligence

BMI

body mass index

blood pressure

CAD

coronary artery disease

confidence interval

CMR

cardiovascular magnetic resonance

serum creatinine

CVD

cardiovascular disease

ESC

European Society of Cardiology

heart rate

LDL-C

LDL-cholesterol

MAP

mean arterial pressure

MOLLI

modified look-locker inversion recovery

magnetic resonance

NAKO

German National Cohort

standard deviation

thyroid disease

German National Cohort (NAKO)

T1 mapping

cardiovascular magnetic resonance

myocardium

cardiometabolic

cardiovascular disease

Myocardial Native T1 Mapping in the German National Cohort (NAKO): Associations with Age, Sex, and Cardiometabolic Risk Factors

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