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N6-methyladenosine-encoded epitranscriptomics
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DOI：10.1038/nsmb.3162.png)
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Abstract
En 中文
N-6-methyladenosine (m(6)A) is the most abundant internal modification in eukaryotic mRNA. Recent discoveries of the locations, functions and mechanisms of m(6)A have shed light on a new layer of gene regulation at the RNA level, giving rise to the field of m(6)A epitranscriptomics. In this Perspective, we provide an update on the various effects of mammalian m(6)A modification, which affects many different stages of the RNA life cycle.
Keywords:
MESSENGER-RNA METHYLATION
SINGLE-NUCLEOTIDE-RESOLUTION
M(6)A RNA
NUCLEAR-RNA
HNRNP C
SEQUENCE SPECIFICITY
MAPPING REVEALS
POLYMERASE-II
YTH DOMAIN
FTO
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