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N6-methyladenosine reader YTHDF2 facilitates malignant progression of gallbladder cancer by suppressing NME1 expression

delete2026-07-24
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PRE
AI
E
En-Liang Zhu
M
Mingjian Ma
X
Xin-Gui Wu
Z
Ze-Chuan Chen
X
Xiang Xu
Y
You Wu
Z
Zhide Liu
Y
Yang‐Yin‐Hui Yu
Z
Zi-Yi Zhao
Q
Qiong‐Cong Xu *
X
Xiaoyu Yin *
DOI：10.1016/j.canlet.2026.218754delete
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Abstract

Abstract

En 中文
• YTHDF2 is aberrantly overexpressed in GBC and independently correlates with poor clinical outcomes. • P300-mediated H3K27ac modification activates YTHDF2 transcription. • YTHDF2 promotes GBC progression by degrading m6A-modified mRNA of the metastasis suppressor NME1. • Combined P300 (C646) and m6A (STM2457) inhibition synergistically suppresses YTHDF2-driven GBC malignancy.

Journal

Cancer Letters cover
Cancer Letters
IF:
10.1
Papers:
1.7W
Citations:
4.3W

Organization

G
guangzhou medical university
Scholars:
5.0K
Papers: 1.3K
Citations: 0
T
the first affiliated hospital of sun yat-sen university
Scholars:
227
Papers: 44
Citations: 0
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