.png){kind=icon}
.png){kind=icon}
Return
Nanoengineered Niclosamide as a Microenvironment Modulator for Spinal Cord Regeneration: A Hypothetical Roadmap Toward Brain/Head Transplant Feasibility
.png){kind=icon}
OA
AI
DOI：10.1002/wnan.70054.png)
.png){kind=icon}
.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
Restoring long-distance spinal cord connectivity remains a major challenge in regenerative medicine. Despite advances in stem cell therapy, biomaterial scaffolds, and neuromodulation, recovery after spinal cord injury (SCI) is limited by a hostile post-injury microenvironment marked by chronic inflammation, glial scarring, and extracellular matrix (ECM) stiffening. This Perspective proposes nanoengineered niclosamide, a repurposable multi-pathway modulator, as a strategy to reprogram this niche. By attenuating NF-κB/STAT3–driven inflammation, suppressing fibrotic signaling, and reducing ECM rigidity, nanoengineered niclosamide may synergize with scaffold- and stimulation-based approaches, highlighting microenvironmental modulation as a realistic path forward for SCI repair.
Keywords:
ECM softening
nanoengineered anti-inflammatory therapy
neural regeneration
spinal cord reconnection
translational neurosurgery
AI Summary
Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.
Journal
W
IF:
0
Papers:
39
Citations:
3