Nanoengineered Shape-Memory Hemostat

doi:10.1002/smsc.202400321

Nanoengineered Shape-Memory Hemostat

2024-12-11

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Akhilesh K. Gaharwar *

DOI：10.1002/smsc.202400321

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Uncontrolled hemorrhage is the predominant cause of preventable combat deaths. Various biomaterials serve as hemostatic agents due to their procoagulant or absorptive activity. However, these biomaterials often lack expansion capabilities, which severely limits use in noncompressible wounds. This study combines a hemostatic nanocomposite with a shape-memory polymer foam to design a composite material with both hemostatic and physical expansion properties. This composite is fabricated in two formulations: a foam externally coated in a highly concentrated nanocomposite (coated composite) and a foam containing a diluted nanocomposite infused throughout its pores (infused composite). Both formulations retain the shape-memory foam's expansion property. Further, the coated composite shows improved fluid uptake (>2-fold) versus infused composites or foam. The nanocomposite component dissociates from the foam under degradative conditions, with the foam remaining stable for 30 days. Hemostatic studies illustrate that the coated composite reduces the clotting time by approximate to 20%. Alternatively, the infused composite improves clotting over a larger distance (up to approximate to 2x distance from the composite). These results signify a modular hemostatic ability: the coated composite reduces clotting and improves fluid uptake, while the infused composite achieves diffuse clotting and maintains mechanical properties. Thus, these materials pose a strong potential for use in noncompressible wounds.

Keywords:

expandable biomaterials

hemostats

nanocomposites

porous materials

wound healing

Nanoengineered Shape-Memory Hemostat

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