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Nanoparticle Biofunctionalization of Bioprosthetic Heart Valves to Modulate Mechanisms of Structural Valve Deterioration
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DOI：10.1016/j.jacbts.2026.101641.png)
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Abstract
En 中文
• Bioprosthetic leaflets fail due to thrombosis, inflammation, and calcification. • PPN rapidly coats leaflets by simple dip coating without impairing valve mechanics. • PPN-Apixaban coated pericardium reduced thrombus and platelet aggregation ex vivo. • PPN-MCC950 and PPN-phytic acid coatings reduced fibrosis and calcification in vivo. • PPN is a scalable coating enabling drug immobilization on valve leaflets.
Keywords:
drug immobilization
nanotechnology
structural valve deterioration
surface functionalization
valve coating
ELISA
enzyme-linked immunosorbent assay
HCAEC
human coronary artery endothelial cell
IL-1β
interleukin-IL-1β
PBS
phosphate-buffered saline
PF4
platelet factor 4
PPN
plasma polymerized nanoparticle
SEM
scanning electron microscopy
SLT
subclinical leaflet thrombosis
SVD
structural valve deterioration
TNF-α
tumor necrosis factor-α
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