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Nanoparticles in Active Targeting Strategies for Cancer Therapy: Advancing Frontiers in Chemotherapy Enhancement
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DOI：10.1002/adtp.202500585.png)
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Abstract
En 中文
Chemotherapy remains a cornerstone of cancer treatment, and chemotherapeutic agents are administered in various forms to a wide range of patients. However, its efficacy is typically limited by nonspecific toxicity. Active targeted nanoparticles (NPs) have emerged as a promising strategy for chemotherapeutic drug delivery. However, after nanocarriers enter the bloodstream, they face multiple barriers such as blood circulation, the tumor microenvironment, cellular uptake, and multidrug resistance (MDR). These barriers prevent nanocarriers from achieving their expected efficacy, ultimately hindering their clinical translation. This review begins with an introduction to the active targeting strategies for NP-based carriers. It then presents the main biological barriers encountered by nanocarriers, from the blood to cells, and systematically explores the multifaceted contributions of active targeted NPs to improving therapeutic outcomes on the systemic, cellular, and molecular levels by prolonging blood circulation, enabling controlled drug release, and reversing MDR. Furthermore, this review highlights the recent advances in NP-mediated combination therapies, including magnetic hyperthermia, photothermal therapy, photodynamic therapy, and sonodynamic therapy, emphasizing their potential for enhancing chemotherapeutic efficacy. Finally, the progress and current limitations of nanocarriers in clinical applications are discussed. This review provides innovative perspectives for the development of advanced NP-based chemotherapeutic nanocarriers.
Keywords:
biological barrier
combination therapy
drug-delivery system
enhancing chemotherapy efficacy
nanoparticle
Journal
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