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Nanoscale morphometric visualization of the endoplasmic reticulum under stress using a bright zinc complex

delete2026-03-01
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PRE
AI
A
Abdul Salam
G
Goraksha T. Sapkal
B
Bodhidipra Mukherjee
S
Sakshi Chouhan
R
Richa Garg
S
Shilpa Chandra
C
Chayan Kanti Nandi *
DOI：10.1039/d6dt00345adelete
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Abstract

Abstract

En 中文
The endoplasmic reticulum (ER) undergoes dynamic morphological changes during cellular stress and disease, yet specific staining and nanoscale observation are challenging. Here, we report a highly bright, biocompatible, and nontoxic fluorescent Zn-complex for super-resolution imaging of the ER. Super-resolution radial fluctuation microscopy (SRRF) resolved the smallest tubular diameter of the ER (110 nm) and quantified stress-induced morphological remodeling.
Keywords:
CELL-DEATH
PROBES
FLUORESCENCE
DEPLETION
EMISSION
DESIGN

Journal

Dalton Transactions cover
Dalton Transactions
IF:
3.3
Papers:
3.3W
Citations:
7.5W

Organization

I
indian institute of technology system (iit system)
Scholars:
9.3W
Papers: 9.9W
Citations: 93
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