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NATURal history of coronary PlaquE on cardiac computed tomography in individuals without MACE or lipid-lowering therapy: NATURE-CTstudy
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DOI：10.1016/j.jcct.2026.05.002.png)
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Abstract
En 中文
Coronary artery disease (CAD) progression has been examined mainly in cohorts enriched for major adverse cardiovascular events (MACE), a high burden of traditional risk factors, or prior exposure to risk-modifying therapies. In contrast, plaque progression is poorly described in patients without prior MACE and receiving no anti-atherosclerotic treatment who undergo cardiac computed tomography angiography (CCTA) for clinical indications. We therefore investigated atherosclerosis progression in this understudied population using serial CCTA.
Keywords:
AI-QCT
Atherosclerosis Imaging Quantitative Computed Tomography
BMI
Body Mass Index
CAC
Coronary Artery Calcium
CCTA
Coronary Computed Tomography Angiography
CP (V)
calcified plaque volume (volume)
CVRF
Cardiovascular Research Foundation of Southern California
DM
Diabetes Mellitus
FDA
Food and Drug Administration
HDL
High Density Lipoprotein
HU
Hounsfield unit
IQR
Interquartile range
IVUS
intravascular ultrasound
LAP
low attenuation plaque
LDL
Low Density Lipoprotein
MACE
Mayor Adverse Cardiovascular Event
NATURE-CT
Evaluation of NATURal History of Coronary Atherosclerotic Plaque in the Absence of Cardiovascular Events and Cardiovascular Medications on Cardiac Computed Tomography
NCP (V)
non-calcified plaque volume (volume)
OCT
optical coherence tomography
PARADIGM
Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography Imaging
PAV
Percent Atheroma Volume
PROSPECT
Providing Regional Observations to Study Predictors of Events in the Coronary Tree
RPP
Rapid plaque progression
SCOT-HEART
Scottish Computed Tomography of the Heart trial
STEMI
ST-elevation myocardial infarction
TG
Triglycerides
TLI
The Lundquist Institute
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