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Navigating the human gene editing scene and proposing a new governance framework in Africa: from knowledge to policy to action
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DOI：10.3389/fgeed.2026.1866004.png)
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Abstract
En 中文
Gene editing holds both hope and despair; necessitating vigilant; ethicolegal oversight to harness its advancement and avoid unintended effects like off-target effects and mosaicism. Despite efforts; governance fragmentation persists regionally and globally. Africa needs a phased; harmonized; continental governance framework for gene editing that combines regional oversight; national implementation; accountability; data governance; genomic sovereignty; and public participation. Policy harmonization is close to accomplishment; but obstacles persist. This paper proposes a practical continent-wide model anchored on African conformity; national legislative capacities; communal engagement; and data sharing. It presents an operational plan encompassing grassroots; nation-state; and regional regulatory bodies; centralized on a new pan-African agency for optimal oversight and governance. The model incorporates bioethical principlism and Ubuntu philosophy; forming the foundations of accountable and safe gene editing research and practice. Trespassing these foundations is a severe; inter-generational; and irresponsible act. This policy review critically analyzes the literature and evidence around gene editing; examining uncertainties; dilemmas; biases; and gaps in concepts. It presents an interpretation of the analysis in a narrative discourse with policy recommendations and governance reforms. The authors relied on empirical evidence and normative arguments. Gene editing is a multifaceted issue; yet a recourse for many patients with devastating diseases. Global progress has been hindered by procedural and operational defects and the controversy of enhancement versus therapy. Declarations; guidelines; and conventions should be prioritized to achieve universal benefits. A diligent consideration of collective risks is crucial to designing effective and inclusive policies. A multi-level approach is imperative for maintaining momentum and pace in technology development and localization.
Keywords:
CRISPR-Cas9
regulatory frameworks
ethical principles
governance structures
human germline genome editing
Journal
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IF:
4.4
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82
Citations:
893
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Cited Papers