Network dynamics underlying OFF responses in the auditory cortex

Giulio Bondanelli

doi:10.7554/eLife.53151

Network dynamics underlying OFF responses in the auditory cortex

2021-03-24

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DOI：10.7554/eLife.53151

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Abstract

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Across sensory systems, complex spatio-temporal patterns of neural activity arise following the onset (ON) and offset (OFF) of stimuli. While ON responses have been widely studied, the mechanisms generating OFF responses in cortical areas have so far not been fully elucidated. We examine here the hypothesis that OFF responses are single-cell signatures of recurrent interactions at the network level. To test this hypothesis, we performed population analyses of two-photon calcium recordings in the auditory cortex of awake mice listening to auditory stimuli, and compared them to linear single-cell and network models. While the single-cell model explained some prominent features of the data, it could not capture the structure across stimuli and trials. In contrast, the network model accounted for the low-dimensional organization of population responses and their global structure across stimuli, where distinct stimuli activated mostly orthogonal dimensions in the neural state-space.

Keywords:

INFERIOR COLLICULUS

POPULATION-DYNAMICS

ONSET RESPONSES

ODOR REPRESENTATIONS

TEMPORAL ASYMMETRIES

TRANSIENT DYNAMICS

OFFSET RESPONSES

GAIN MODULATION

TONAL STIMULI

NEURONS

Network dynamics underlying OFF responses in the auditory cortex

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