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Neural Substrates of Apathy in Parkinson’s Disease: a systematic review of Structural and Functional Neuroimaging Studies
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DOI：10.1016/j.brainresbull.2026.111922.png)
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Abstract
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• Apathy in Parkinson’s disease is a distinct neuropsychiatric syndrome. • Structural and functional neuroimaging reveal alterations in fronto-striatal-limbic circuits. • Dorsolateral and inferior frontal gyri, ACC, and nucleus accumbens are key regions involved. • Functional and structural connectivity disruptions correlate with apathy severity. • Findings highlight the need for personalized, mechanism-based therapeutic approaches.
Keywords:
Parkinson’s disease
apathy
neuroimaging
functional connectivity
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