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Neuroimaging insights on sleep disturbances and risk for major depressive disorder in youth: A systematic review
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DOI：10.1016/j.comppsych.2026.152728.png)
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Abstract
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• Sleep quality differs in youth, adolescents, and young adults with a high risk for depression. • REM sleep neurophysiology and sleep spindle density differ by depression risk. • Poor sleep was associated with differences in white matter integrity, which in turn predicted future depressive symptoms. • Reward related brain activity in the dorsomedial prefrontal cortex and resting-state salience network activity mediated the relationship between sleep and future depressive symptoms. • Substantial heterogeneity, but low-to-moderate risk of bias, was observed.
Keywords:
Sleep disturbance
Insomnia
Major depressive disorder
Youth depression risk
Brain development
Developmental psychopathology
Neuroimaging
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