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Neuronal Syndecan reduction modulates age- and sex-specific changes in sleep architecture and metabolic remodeling in Drosophila melanogaster
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DOI：10.1016/j.mad.2026.112207.png)
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Abstract
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• Neuronal Syndecan (Sdc) loss leads to changes in Drosophila sleep architecture. • Neuronal Sdc reduction is associated with increased total sleep. • Sleep stability and fragmentation differ by age, sex, and time of the day. • Sdc reduction results in context-dependent changes in metabolism and feeding. • Glutamatergic signaling and kynurenine metabolism are altered with Sdc reduction.
Keywords:
Sleep architecture
Aging
Syndecan
Glutamatergic signaling
Kynurenine pathway
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