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Neuropeptide S alleviates neuropathic pain through lateral hypothalamic orexinergic circuit in rats
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DOI：10.1016/j.ejphar.2026.178927.png)
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Abstract
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• CCI downregulates neuropeptide S (NPS) and its receptor expression in the LH. • Intra-LH infusion of NPS produces antinociceptive effect in CCI rats. • NPS receptor antagonist SHA-68 (intra-LH) exacerbates neuropathic pain. • NPS activates LH-vlPAG orexinergic pathway to produce antinociception. • NPS treatment restored injury-induced neurochemical imbalance in the vlPAG.
Keywords:
Neuropeptide S
neuropathic pain
lateral hypothalamus
orexinergic pathway
vlPAG
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