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Neuroprotective Effects of Rubus idaeus in Amblyopia
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DOI：10.1002/mnfr.70288.png)
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Abstract
En 中文
Amblyopia is a neurodevelopmental disorder characterized by impaired vision in childhood and remains challenging to manage effectively. The present study investigated the neuroprotective potential of Rubus idaeus L. (red raspberry) in a rodent model of amblyopia. Through network pharmacology analysis, the PI3K/AKT axis was identified as a major regulatory target of R. idaeus L. treatment. In vitro, 1 µg/mL of R. idaeus L. significantly enhanced neuronal survival under oxidative stress (82.4% vs. 54.6%, p < 0.01) and reduced apoptotic cell death by 23.5% (p < 0.001). These protective effects correlated with elevated expression of anti-apoptotic proteins (Bcl-2, PI3K) and decreased levels of pro-apoptotic markers (Bax, cleaved caspase-3). In vivo, R. idaeus L. treatment improved visual evoked potentials in a monocular deprivation model, indicated by shorter P100 latency and increased amplitude. These effects were reversed by the PI3K inhibitor LY294002, supporting the involvement of the PI3K/AKT axis. Our findings suggest that R. idaeus L. holds potential as a novel therapeutic approach for amblyopia via modulation of neuroprotective pathways.
Keywords:
amblyopia
Bax
Bcl-2
cleaved caspase
PI3K/AKT signaling pathway
Rubus idaeus L.
visual cortex neurons apoptosis
visual deprivation amblyopia model
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4.2
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1.2K
Citations:
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