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Neutralizing endocan reduces blood pressure and improves endothelial function in angiotensin II-induced hypertensive mice
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DOI：10.1016/j.biopha.2025.118910.png)
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Abstract
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• Elevated circulating endocan levels contribute to blood pressure elevation and vascular dysfunction in hypertension. • Endocan induces endothelial dysfunction by TNF-α–dependent inhibition of eNOS phosphorylation and NO bioavailability. • Endocan neutralization attenuates hypertension and improves vascular function in Ang II–induced hypertension mice. • Endocan may serve as a promising therapeutic target for managing hypertension and associated cardiovascular complications.
Keywords:
Hypertension
Angiotensin Ⅱ
Endocan
Esm-1
Vascular endothelial dysfunction
eNOS
Nitric oxide
TNF-α
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B
IF:
7.5
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1.6W
Citations:
8.2W
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