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Ni-Catalyzed Regio- and Enantioselective Synthesis of P-Chiral Dienyl Secondary Phosphine Oxides
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PRE
AI
J
C
W
张
DOI：10.1002/ajoc.70482.png)
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Abstract
En 中文
P-chiral secondary phosphine oxides (SPOs) are pivotal precursors to valuable P-Chiral phosphorus compounds, yet their asymmetric synthesis remains a challenge due to their propensity for racemization. Herein, we report a nickel-catalyzed hydrophosphorylation of primary phosphine oxides (PPOs) with conjugated enynes to construct P-chiral dienyl SPOs. This method displays high regioselectivity and broad tolerance for a wide range of conjugated enyne substrates. The resulting products have the potential to serve as valuable precursors to bidentate ligands, as well as versatile synthons for accessing P-stereogenic phosphines.
Keywords:
hydrofunctionalization
hydrophosphorylation
Ni-catalysis
P-chiral SPOs
P-stereogenic center
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