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Nickel catalyzed reductive cross-coupling for the construction of aryl-substituted alkylidenecyclobutanes

delete2026-03-01
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PRE
AI
C
Cen, Min
Y
Yi, Anqi
W
Wu, Tao *
DOI：10.1016/j.tetlet.2026.156066delete
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Abstract

Abstract

En 中文
Alkylidenecyclobutanes constitute an important class of structural motifs. Herein, we report a nickel-catalyzed reductive cross-coupling between bromoalkylidenecyclobutanes and aryl halides using inexpensive and readily available zinc powder as the reductant, providing efficient access to substituted alkylidenecyclobutanes. This transformation features a broad substrate scope and excellent functional-group tolerance. The products can be further elaborated into more complex architectures containing cyclobutane rings. Preliminary mechanistic investigations suggest a radical-based pathway.
Keywords:
Alkylidenecyclobutanes
Reductive cross-coupling
Nickel catalysis
Bromoalkylidenecyclobutanes
Radical pathway

Journal

T
Tetrahedron Letters
IF:
1.5
Papers:
148
Citations:
4.2W

Organization

N
nanchang university
Scholars:
7.2K
Papers: 2.0K
Citations: 0
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