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NIR-II light in clinical oncology: opportunities and challenges
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DOI：10.1038/s41571-024-00892-0.png)
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Abstract
En 中文
Novel strategies utilizing light in the second near-infrared region (NIR-II; 900-1,880 nm wavelengths) offer the potential to visualize and treat solid tumours with enhanced precision. Over the past few decades, numerous techniques leveraging NIR-II light have been developed with the aim of precisely eliminating tumours while maximally preserving organ function. During cancer surgery, NIR-II optical imaging enables the visualization of clinically occult lesions and surrounding vital structures with increased sensitivity and resolution, thereby enhancing surgical quality and improving patient prognosis. Furthermore, the use of NIR-II light promises to improve cancer phototherapy by enabling the selective delivery of increased therapeutic energy to tissues at greater depths. Initial clinical studies of NIR-II-based imaging and phototherapy have indicated impressive potential to decrease cancer recurrence, reduce complications and prolong survival. Despite the encouraging results achieved, clinical translation of innovative NIR-II techniques remains challenging and inefficient; multidisciplinary cooperation is necessary to bridge the gap between preclinical research and clinical practice, and thus accelerate the translation of technical advances into clinical benefits. In this Review, we summarize the available clinical data on NIR-II-based imaging and phototherapy, demonstrating the feasibility and utility of integrating these technologies into the treatment of cancer. We also introduce emerging NIR-II-based approaches with substantial potential to further enhance patient outcomes, while also highlighting the challenges associated with imminent clinical studies of these modalities. Expansion of the utilizable spectrum of light from the visible region to the near-infrared (NIR) window has greatly facilitated the clinical application of optical technologies for cancer imaging and phototherapy. However, use of light in the first NIR region (NIR-I) has important limitations, some of which might be overcome with emerging technologies utilizing NIR-II light. In this Review, the authors describe the current clinical experience with NIR-II-based cancer imaging and phototherapy, and discuss emerging NIR-II-based approaches that might further enhance patient outcomes. They also highlight challenges that will need to be addressed to translate NIR-II-based modalities from bench to bedside. Extending the clinical imaging spectrum to the second near-infrared (NIR-II) window offers greatly improved visualization of multiple features of cancer, providing a promising approach for enhancing surgical quality and facilitating oncological research.The efficacy of phototherapy can be substantially improved through the use of NIR-II irradiation, with the potential to improve therapeutic selectivity for cancer and facilitate the development of innovative combination therapies.Early phase clinical studies of NIR-II image-guided surgery and phototherapy for solid tumours have demonstrated promising potential to improve resection rates, reduce complications and prolong survival.Facilitating clinical application will be the primary objective for the future development of NIR-II techniques; a cyclical flow from bench to bedside and back again is necessary to promote this clinical translation.Emerging NIR-II techniques should aim to complement and enhance existing approaches rather than replace them; exploiting incremental value is essential to translating these novel approaches into clinical practice.Advances in NIR-II techniques might greatly facilitate a paradigm shift in cancer imaging, surgery and phototherapy, ultimately improving patient outcomes.
Keywords:
INDUCED INTERSTITIAL THERMOTHERAPY
GUIDED CANCER-SURGERY
IN-VIVO
ARTIFICIAL-INTELLIGENCE
INDOCYANINE GREEN
THERMAL THERAPY
FLUOROPHORES
WINDOW
LIVER
CHOLANGIOGRAPHY
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82.2
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2.3K
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