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NMDA Receptor Contributions to Visual Contrast Coding
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DOI：10.1016/j.neuron.2010.06.020.png)
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Abstract
En 中文
In the retina, it is not well understood how visual processing depends on AMPA- and NMDA-type glutamate receptors. Here we investigated how these receptors contribute to contrast coding in identified guinea pig ganglion cell types in vitro. NMDA-mediated responses were negligible in ON alpha cells but substantial in OFF alpha and delta cells. OFF delta cell NMDA receptors were composed of GluN2B subunits. Using a novel deconvolution method, we determined the individual contributions of AMPA, NMDA, and inhibitory currents to light responses of each cell type. OFF alpha and delta cells used NMDA receptors for encoding either the full contrast range (alpha), including near-threshold responses, or only a high range (delta). However, contrast sensitivity depended substantially on NMDA receptors only in OFF alpha cells. NMDA receptors contribute to visual contrast coding in a cell-type-specific manner. Certain cell types generate excitatory responses using primarily AMPA receptors or disinhibition.
Keywords:
RETINAL GANGLION-CELLS
AMINO-ACID RECEPTORS
IONOTROPIC GLUTAMATE RECEPTORS
EXCITATORY SYNAPTIC CURRENTS
D-ASPARTATE RECEPTORS
MOUSE BARREL CORTEX
CONE BIPOLAR CELLS
RABBIT RETINA
RAT RETINA
FUNCTIONAL-ORGANIZATION
Journal
IF:
15
Papers:
1.4W
Citations:
9.9W
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