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Nobiletin ameliorates hepatic insulin resistance by modulating the gut–liver axis
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DOI：10.1016/j.jnutbio.2026.110452.png)
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Abstract
En 中文
• NOB effectively ameliorated IR in both high-fat diet/streptozotocin (HFD/STZ)-induced mice and palmitic acid (PA)-treated HepG2 cells. • NOB reduced lipid accumulation in both the mouse liver and HepG2 cells. • NOB suppressed hepatic gluconeogenesis through activation of the PI3K/AKT/FOXO1 signaling pathway. • NOB also enhanced the intestinal barrier and ameliorated gut microbiota dysbiosis.
Keywords:
Nobiletin
Hepatic insulin resistance
Lipid metabolism
PI3K/AKT/FOXO1
Gut microbiota
Gut-liver axis
ACC1
,
Acetyl-CoA carboxylase 1
ACC2
,
acetyl-CoA carboxylase 2
AKT
,
protein kinase
Anosim
,
analysis of similarities B
FOXO1
,
forkhead box protein O1
ChREBP
,
carbohydrate-responsive element-binding protein
CMC-Na
,
carboxymethyl cellulose sodium
CPT1A
,
Carnitine palmitoyl transferase 1A
DAG
,
diacylglycerol
DCFH-DA
,
2′,7′-dichlorodihydrofluorescein diacetate
DEGs
,
differentially expressed genes
DMEM
,
Dulbecco’s modified Eagle’s medium
DNL
,
de novo lipogenesis
FABP1
,
Fatty acid-binding protein 1
FAO
,
fatty acid β-oxidation
FASN
,
fatty acid synthase
FATP5
,
fatty acid transport protein 5
FFA
,
Free fatty acids
FMT
,
fecal microbiota transplantation
G6Pase
,
glucose-6-phosphatase
GLUT2
,
glucose transporter 2
HFD
,
high-fat diet
IDF
,
International Diabetes Federation
INSR
,
insulin receptor
IR
,
Insulin resistance
IRS-1/2
,
insulin receptor substrate 1/2
LDA
,
linear discriminant analysis
LEfSe
,
Linear discriminant analysis effect size
LFD
,
low-fat diet
LPS
,
lipopolysaccharide
MET
,
metformin
NAFLD
,
non-alcoholic fatty liver disease
NAS
,
non-alcoholic fatty liver disease activity score
NOB
,
Nobiletin
PA
,
palmitic acid
PCA
,
principal component analysis
PEPCK
,
Phosphoenolpyruvate carboxykinase
PI3K
,
phosphoinositide 3-kinase
PKCε
,
protein kinase C epsilon
PPAR
,
Peroxisome proliferator-activated receptor
PPARα
,
peroxisome proliferator-activated receptor alpha
SCD1
,
Stearoyl-CoA desaturase 1
SCFAs
,
short-chain fatty acids
SREBP-1c
,
sterol regulatory element-binding protein 1c
STZ
,
streptozotocin
T2DM
,
type 2 diabetes mellitus
TLR4
,
Toll-like receptor 4
Journal
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4.5K
Citations:
1.4W
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