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Non-activated Esters as Reactive Handles in Direct Post-Polymerization Modification
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DOI：10.1002/anie.202303841.png)
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Abstract
En 中文
Non-activated esters are prominently featured functional groups in polymer science, as ester functional monomers display great structural diversity and excellent compatibility with a wide range of polymerization mechanisms. Yet, their direct use as a reactive handle in post-polymerization modification has been typically avoided due to their low reactivity, which impairs the quantitative conversion typically desired in post-polymerization modification reactions. While activated ester approaches are a well-established alternative, the modification of non-activated esters remains a synthetic and economically valuable opportunity. In this review, we discuss past and recent efforts in the utilization of non-activated ester groups as a reactive handle to facilitate transesterification and aminolysis/amidation reactions, and the potential of the developed methodologies in the context of macromolecular engineering.
Keywords:
Amidation
Catalysis
Polymers
Post-Polymerization Modification
Transesterification
Journal
IF:
16.9
Papers:
5.6W
Citations:
53.0W