.png){kind=icon}
Return
Non-coding RNA
.png){kind=icon}
PRE
AI
DOI：10.1093/hmg/ddl046.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
The term non-coding RNA (ncRNA) is commonly employed for RNA that does not encode a protein, but this does not mean that such RNAs do not contain information nor have function. Although it has been generally assumed that most genetic information is transacted by proteins, recent evidence suggests that the majority of the genomes of mammals and other complex organisms is in fact transcribed into ncRNAs, many of which are alternatively spliced and/or processed into smaller products. These ncRNAs include microRNAs and snoRNAs (many if not most of which remain to be identified), as well as likely other classes of yet-to-be-discovered small regulatory RNAs, and tens of thousands of longer transcripts (including complex patterns of interlacing and overlapping sense and antisense transcripts), most of whose functions are unknown. These RNAs (including those derived from introns) appear to comprise a hidden layer of internal signals that control various levels of gene expression in physiology and development, including chromatin architecture/epigenetic memory, transcription, RNA splicing, editing, translation and turnover. RNA regulatory networks may determine most of our complex characteristics, play a significant role in disease and constitute an unexplored world of genetic variation both within and between species.
Keywords:
NATURAL ANTISENSE TRANSCRIPTS
GENE-EXPRESSION
INTERGENIC TRANSCRIPTION
ESCHERICHIA-COLI
COMPUTATIONAL IDENTIFICATION
DEVELOPMENTAL REGULATION
ULTRACONSERVED ELEMENTS
MAMMALIAN MICRORNAS
CONSERVED ELEMENTS
TRANS-INTERACTION
AI Summary
Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.
Journal
IF:
3.2
Papers:
1.1W
Citations:
3.5W
Organization
No organization information available
Cited Papers
ShareSaveShareSaveShareSaveThe noncoding RNA Taurine upregulated gene 1 is required for differentiation of the murine retina.png)
CURRENT BIOLOGY
OAAI
CURRENT BIOLOGYIF7.5
OAAIShareSaveShareSaveShareSave
View more