Noncanonical ion channel signaling in neurovascular barrier regulation and immune cell trafficking

Laura Vinnenberg

doi:10.1016/j.coi.2026.102813

Noncanonical ion channel signaling in neurovascular barrier regulation and immune cell trafficking

2026-07-06

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AI

L

Laura Vinnenberg

B

Bart Jan Ravoo

C

Christos Gatsogiannis

T

Thomas Budde

S

Sven G Meuth

DOI：10.1016/j.coi.2026.102813

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Abstract

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• Noncanonical mechanisms diversify the biological output of ion channels. • Spatiotemporal restriction of ion flux shapes cell fate, distinct from global currents. • Dissecting canonical and noncanonical functions enables precision therapy. • Noncanonical inflammation-induced junctional remodeling compromises BBB integrity.

Noncanonical ion channel signaling in neurovascular barrier regulation and immune cell trafficking

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