Nonparametric input estimation in physiological systems: Problems, methods, and case studies

doi:10.1016/S0005-1098(96)00254-3

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Nonparametric input estimation in physiological systems: Problems, methods, and case studies

1997-05-01

148

PRE

DeNicolao, G

Giovanni Sparacino

Claudio Cobelli

DOI：10.1016/S0005-1098(96)00254-3

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Abstract

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Input estimation from output data is an important problem in the analysis of physiological systems, because many signals of interest are not directly accessible to measurement. When the system is time-invariant, this problem is often referred to as deconvolution. Three representative physiological problems, regarding hormone secretion, insulin dynamics, and hepatic glucose production, are used to illustrate the major challenges: ill-conditioning, confidence intervals assessment, infrequent and nonuniform sampling, nonnegativity constraints, and computational efficiency. The paper provides a critical overview of the existing techniques, focusing on regularization theory and Bayesian estimation. In order to overcome some inadequacies of the existing methods, some new results are derived. In particular, the connection between the maximum-likelihood estimate of the regularization parameter and the notion of equivalent degree of freedom is studied. Moreover, a fast SVD-based numerical algorithm is developed that includes the optimization of the regularization parameter, and the computation of confidence intervals. The proposed techniques are validated on a benchmark problem and are shown to provide effective solutions to the three physiological case studies. (C) 1997 Elsevier Science Ltd.

Keywords:

deconvolution

inverse problems

input estimation

smoothing

biomedical systems

endocrinology

insulin

luteinizing hormone

glucose dynamics

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