Nortriptyline-targeted siRNA-loaded liposomes: Design, affinity, biodistribution, and bioactivity in a murine Herpes Simplex Virus 1 corneal infection model

Doaa Jbara-Agbaria

doi:10.1016/j.ejps.2025.107388

Nortriptyline-targeted siRNA-loaded liposomes: Design, affinity, biodistribution, and bioactivity in a murine Herpes Simplex Virus 1 corneal infection model

2025-11-27

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Natalia Callai Da Silva

DOI：10.1016/j.ejps.2025.107388

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• Nortriptyline (NTP) decorated siRNA (siHSV1) liposomes were successfully formulated • The targeted liposomes exhibited optimal physicochemical properties • Enhanced affinity to neuronal cells and the trigeminal ganglia was achieved • Topical gel-laden siHSV1 liposomes reduce herpes simplex keratitis in a mouse model • Targeted liposomes are promising in combating latent HSV1 in the trigeminal ganglia

Keywords:

siRNA/siHSV1 liposomes

herpes simplex virus 1

nortriptyline targeted delivery

trigeminal ganglia

ICP0

herpes simplex keratitis

Nortriptyline-targeted siRNA-loaded liposomes: Design, affinity, biodistribution, and bioactivity in a murine Herpes Simplex Virus 1 corneal infection model

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