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Notch-mediated lateral inhibition is shaped by morphological differences to reinforce bias toward signal-sending or -receiving roles
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DOI：10.1016/j.cub.2026.07.041.png)
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Abstract
En 中文
• No Notch-target gene transcription in presumptive neuroblast of proneural clusters • Size and tension differences influence selection of the signal-sending neuroblast • Mechanics and neuroblast delamination shape the Notch transcriptional response • Lateral-inhibition models incorporating area and tension recapitulate Notch outputs
Keywords:
Notch
lateral inhibition
live transcription
cell mechanics
mathematical modeling
Drosophila
neurogenesis
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