Novel Indole based thiazolotriazole as diabetic inhibitors: Synthesis, biological evaluation, in-silico molecular docking and simulation study

doi:10.1016/j.molstruc.2025.145133

Novel Indole based thiazolotriazole as diabetic inhibitors: Synthesis, biological evaluation, in-silico molecular docking and simulation study

2025-12-22

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Muhammad Taha Muhammad Taha *

DOI：10.1016/j.molstruc.2025.145133

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• Novel Indole based thiazolotriazole derivatives were synthesized. • All synthesized derivatives were characterized by diverse analytical methods. • All synthesized compounds were also tested for against α-amylase and α-glucosidase inhibition. • The structure-activity relationships study was carried out. • The molecular docking and simulation studies were carried out.

Novel Indole based thiazolotriazole as diabetic inhibitors: Synthesis, biological evaluation, in-silico molecular docking and simulation study

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