Novel mechanisms linking platelet activation to antiphospholipid syndrome

Marina Camera

doi:10.1016/j.coi.2026.102791

Novel mechanisms linking platelet activation to antiphospholipid syndrome

2026-05-29

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M

Marina Camera

E

Elena Tremoli

P

Paola A Lonati

P

Pier L Meroni

DOI：10.1016/j.coi.2026.102791

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• Increased evidence supports the persistent platelet activation in APS. • APS platelets display not only proadhesive but also procoagulant (TFpos) phenotype. • Increase of TFpos-platelet-leukocyte aggregates is a marker of platelet activation. • TFpos-platelet/TFpos-platelet -leukocyte aggregates may increase the thrombotic risk. • The two-hit APS model should evolve into a multi-hit model.

Novel mechanisms linking platelet activation to antiphospholipid syndrome

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