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Novel synthesis and functionalization of enaminone intermediate using bimetallic Pd-Cu anchored cellulose supported-MOF via heck coupling reaction
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DOI：10.1007/s11164-026-06068-y.png)
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Abstract
En 中文
The preparation of biologically active compounds, such as enaminones, has been continuously scrutinized in the search for the best catalyst to make the process greener, more efficient, and more sustainable. The present article discloses the fabrication of a bimetallic Pd-Cu-anchored cellulose-supported metal–organic framework i.e. RH-CNC@NH2-BDC-Fe@Pd-Cu, where RH-CNC was derived from agrowaste rice husk. The formation of the catalyst was confirmed by various physicochemical characterizations using FTIR, Raman, FESEM, EDX, XRD, XPS, BET, and TGA, which indicate successful immobilization, structural integrity, and magnetic recoverability. The fabricated catalyst was used to synthesize enaminone derivatives from dimedone via a sequential one-pot Heck coupling reaction. The enaminone product 5a was further explored for the synthesis of a bioactive azepinone framework. To assess the catalyst efficacy, the reaction was studied with a series of substrates, yielding excellent yields and remarkable catalytic cycles.
Keywords:
Enaminone
MOF
Organic synthesis
Bimetallic
Heck coupling
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3.5
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634
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