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NOX1 drives inflammatory bowel disease through oxidant-dependent stabilization of IκBζ
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DOI：10.1016/j.freeradbiomed.2026.07.037.png)
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Abstract
En 中文
• NOX1 and IκBζ were upregulated in colonic tissues and organoids from IBD patients. • NOX1 controls IκBζ expression in inflammatory conditions. • ROS oxidize IκBζ on Cys638 rendering it resistant to proteasomal degradation. • NOX1-IκBζ axis controls inflammatory gene networks, including the hub gene CCL2. • In IBD patients, high CCL2 levels correlate with IκBζ oxidation and stabilization.
Keywords:
NOX1
NOXO1
IκBζ
ROS
Inflammatory bowel disease
NOX
NADPH oxidase
IκBζ
Inhibitor of nuclear factor kappa B zeta
ROS
reactive oxygen species
IBD
inflammatory bowel disease
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