.png){kind=icon}
Return
Nuclear export complexes in the frame
.png){kind=icon}
PRE
AI
DOI：10.1016/j.sbi.2010.01.012.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
Protein and RNA molecules are exchanged between the nucleus and cytoplasm by members of the karyopherin beta family of transport factors. Karyopherins adopt a modular HEAT-repeat architecture and are regulated by the GTPase Ran. RanGTP acts as a signal for the nuclear compartment, dissociating molecular cargo from karyopherins that mediate nuclear import and promoting cargo uptake on those mediating nuclear export. After unraveling the mechanisms of nuclear import factors, structural studies have recently provided tremendous insights into nuclear export. The impact of RanGTP binding on the karyopherins ranges from large, global conformational changes to local, allosteric effects. A theme emerges where cargo recognition provides a molecular surveillance mechanism to prevent the transport of macromolecules in an inappropriate state.
Keywords:
STRUCTURAL BASIS
IMPORTIN ALPHA
LOCALIZATION SIGNAL
CRYSTAL-STRUCTURE
TRANSFER-RNA
RECEPTOR
TRANSPORT
CRM1
RECOGNITION
KARYOPHERIN
AI Summary
Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.
Journal
IF:
7
Papers:
3.8K
Citations:
1.3W
Organization
Cited Papers
No cited papers available