.png){kind=icon}
.png){kind=icon}
Return
Obstructive Sleep Apnea Syndrome and Ischemic Stroke: Investigating Inflammatory Mechanisms
.png){kind=icon}
OA
AI
Z
Z
Z
X
W
T
R
DOI：10.2147/NSS.S581040.png)
.png){kind=icon}
.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
Obstructive Sleep Apnea Syndrome (OSAS) is characterized by repeated episodes of complete (apnea) or partial (hypopnea) collapse of the upper airway during sleep, leading to chronic intermittent hypoxia and/or hypercapnia, and sleep fragmentation. This review systematically examines the mechanisms linking OSAS and ischemic stroke, with particular emphasis on the roles of the PI3K/Akt signaling pathway, Toll-like receptor signaling pathway, and NLRP3 inflammasome in OSAS-related inflammatory responses, and their contributions to the pathogenesis and progression of ischemic stroke. We also explore how OSAS affects stroke recovery through impaired sleep quality and increased cardiovascular stress, potentially worsening prognosis. This article discusses potential anti-inflammatory therapeutic strategies, underscores the importance of early OSAS intervention in reducing recurrence and improving outcomes, and offers new perspectives on OSAS-related ischemic stroke mechanisms and clinical management.
Keywords:
obstructive sleep apnea syndrome
ischemic stroke
inflammatory mechanisms
signalling pathways
AI Summary
Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.
Journal
IF:
3.4
Papers:
1.2K
Citations:
3.2K
View more organizations