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Oculomics and AI: The eye as a biomarker for health span
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DOI：10.1016/j.apjo.2026.100282.png)
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Abstract
En 中文
As the world's population ages, the focus of healthcare is shifting from extending life span to promoting health span. There is an unmet need to identify sensitive and reliable markers of health span through more cost-effective and non-invasive methods, to enable early and effective intervention on modifiable aging factors. The eye offers a unique window into systemic health, providing direct visualization of the body's vascular and neural health. This review presents an overview of how various ocular structures can serve as biomarkers of health span-drawing on insights from ocular imaging, metabolomics, and proteomics, with evidence from basic science, animal models, and human clinical trials. The role of artificial intelligence (AI) in predicting biological age and the risk
Keywords:
Artificial intelligence
Healthcare
Longevity
Metabolomics
Proteomics
Ocular imaging
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