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OcupHI: knowledge-driven colorimetric interpretation framework for high-precision real-time ocular pH diagnostics
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DOI：10.1007/s42247-026-01492-7.png)
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Abstract
En 中文
Ocular injuries due to chemical spills pose a substantial concern, representing 10–22% of all ocular trauma. Although precise detection of ocular pH is crucial for determining the optimal medical treatment, many existing methods remain invasive, biased, or insufficiently precise. Reliance on subjective visual assessment of subtle color differences limits the objectivity and hinders high-throughput analysis. Therefore, an advanced colorimetric knowledge-driven ocular pH detection method was developed using a biosensor (OcupHI) based on a Clitoria ternatea (Butterfly Pea) anthocyanin sensing agent. The proposed work delivers fast, high-precision, and easily measurable pH prediction across clinically relevant ranges, while supporting real-time decision support for eye physicians. The pH range from 1 to 12 was tested and compared with six different anthocyanin concentrations: 5, 10, 20, 30, 40, and 50 ppm, and five different machine learning models, namely, Decision Tree (DT), K-Nearest Neighbors (KNN), Random Forest (RF), Extreme Gradient Boosting (XGBoost), and Support Vector Machines (SVM). The results revealed that the 40 ppm anthocyanin concentration trained with the XGBoost model produced the most accurate ocular pH values, achieving superior performance with an overall accuracy of 96%, a significantly higher F1-score for early detection. Experimental validation clearly demonstrates strong predictive accuracy, robustness, and interpretability, highlighting the potential for next-generation ocular diagnostics. Further research findings support Sustainable Development Goal (SDG) 3 – good health and well-being through a real-time ocular pH monitoring kit, and SDG 12 – responsible consumption and production by optimizing the use of the natural colorant anthocyanin for sensor development.
Keywords:
Ocular pH Detection
Colorimetry
Anthocyanin
Real-time pH classification
Artificial Intelligence (AI)
Machine learning (ML)
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503
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