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Off-Chip-Controlled Droplet-on-Demand Method for Precise Sample Handling

delete2020-04-23
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OA
AI
M
Medina Hamidović
U
Uli Marta
H
Helen Bridle
D
Damir Hamidović
G
Gerold Fink
R
Robert Wille
A
Andreas Springer
W
Werner Haselmayr *
DOI:10.1021/acsomega.9b03883delete
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Abstract

Abstract

En 中文
We present a simple, stable, and highly reproducible off-chip-controlled method for generating droplets-on-demand. To induce the droplet generation, externally pre-programmed positive pressure pulses are applied to the dispersed phase input while the continuous phase channel remains at constant input pressure. By controlling solely one fluid phase, the method allows for connecting multiple independent dispersed-phase channels to a single continuous channel. Experimental results show that the method allows for a droplet generation frequency of 33 Hz and a high reproducibility of droplets with standard deviations less than 5% of the mean value. Moreover, utilization of the off-chip-controlled method results in the simplicity in chip design and allows rapid (similar to 5 min) and cost-efficient (0.5 USD) prototyping of the device.
Keywords:
GENERATION
BIOLOGY
SYSTEMS
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Journal

ACS Omega cover
ACS Omega
IF:
4.3
Papers:
3.3W
Citations:
9.8W

Organization

J
Johannes Kepler University Linz
Scholars:
5.5K
Papers: 4.6K
Citations: 106
H
Heriot Watt University
Scholars:
6.0K
Papers: 6.4K
Citations: 57