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Off-protocol radiotherapy in prospective systemic therapy trials for metastatic non-small cell lung cancer
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DOI：10.1016/j.cllc.2026.05.009.png)
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Abstract
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• Radiotherapy is increasingly delivered to patients with metastatic NSCLC. • Radiotherapy may affect toxicity and/or outcomes data from systemic therapy trials. • Radiotherapy use during and before systemic therapy trials is infrequently reported. • Future systemic therapy trials should consider radiation during protocol design.
Keywords:
Non-small cell lung cancer
NSCLC
metastatic
targeted therapy
Immunotherapy
Systemic Therapy
Radiotherapy
radiation
Clinical trial
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