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Oleoylethanolamide attenuates early skeletal muscle metabolic remodeling induced by short-term high-fat diet exposure
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DOI：10.1016/j.phrs.2026.108350.png)
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Abstract
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• Short-term obesogenic diet induces early skeletal muscle metabolic remodeling. • Early HFD exposure promotes muscle lipid accumulation and energetic imbalance. • OEA limits intramuscular lipid accumulation and restores fatty acid oxidative handling. • OEA attenuates mitochondrial stress, oxidative damage, and altered metabolic signaling. • OEA preserves muscle structural integrity and counteracts early fibrotic remodeling.
Keywords:
Oleoylethanolamide
High-fat diet
Muscle fibrosis
Mitochondrial dysfunction
Oxidative stress
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