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Oncofetal reprogramming in tumour development and progression
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DOI：10.1038/s41568-022-00497-8.png)
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Abstract
En 中文
Embryonic development is characterized by rapidly dividing cells, cellular plasticity and a highly vascular microenvironment. These features are similar to those of tumour tissue, in that malignant cells are characterized bytheir abilityto proliferate and exhibit cellular plasticity. The tumour microenvironment also often includes immunosuppressive features. Reciprocal communication between various cellular subpopulations enables fetal and tumourtissues to proliferate, migrate and escape immune responses. Fetal-like reprogramming has been demonstrated in the tumour microenvironment, indicating extraordinary cellular plasticity and bringing an additional layer of cellular heterogeneity. More importantly, some of these features are also present during inflammation. This Perspective discusses the similarity between embryogenesis, inflammation and tumorigenesis, and describes the mechanisms of oncofetal reprogramming that enable tumour cells to escape from immune responses, promoting tumour growth and metastasis.
Keywords:
MIGRATION-STIMULATING FACTOR
EPITHELIAL-MESENCHYMAL TRANSITION
SINGLE-CELL TRANSCRIPTOMES
ALPHA-FETOPROTEIN
CARCINOEMBRYONIC ANTIGEN
ALVEOLAR MACROPHAGES
FETAL MONOCYTES
COLORECTAL-CANCER
FIBROBLASTS
MYC
Journal
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66.8
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3.8K
Citations:
6.0W